Avascular necrosis (AVN), or more correctly “osteonecrosis”, is a generic term referring to an ischaemic death of the constituents of bone.
AVN has a wide variety of causes and can affect nearly any bone in the body. Most sites of involvement have an eponym associated with avascular necrosis of that area, and these sites are discussed individually as each site has unique clinical, etiologic and prognostic features.
The terms ischaemic and avascular necrosis are typically reserved for subchondral osteonecrosis, whereas bone infarct refers to medullary osteonecrosis.
There is no single affected demographic as the underlying predisposing factors are varied.
Infarction begins when the blood supply to a section of bone is interrupted. Once an infarct has become established, just as in other tissues, there is a central necrotic core, surrounded by an ischaemic zone, the inner portion being ‘almost dead’ and the outer portion being hyperaemic. Beyond this is normal viable marrow. Between the normal and the ischaemic zone that demarcation occurs with the development of viable granulation separating dead tissue. This leads to the double line sign on MRI.
When the infarct is subchondral, a wedge of tissue is typically affected, the apex of which points towards the centre of the bone.
•trauma (fracture or dislocation)
•Increased pressure inside the bone
• Blood Clot disorders,haemoglobinopathies, e.g. sickle cell disease
•connective tissue disorders and vascular issues
•corticosteroid excess (both endogenous and exogenous)
•alcohol and smoking
Mnemonics: STARS, PLASTIC RAGS
Eponymous names for specific sites of avascular necrosis
• Ahlback disease: medial femoral condyle, i.e. SONK
• Brailsford disease: head of radius
• Buchman disease: iliac crest
• Burns disease: distal ulna
• Caffey disease: entire carpus or intercondylar spines of tibia
• Dias disease: trochlea of the talus
• Dietrich disease: head of metacarpals
• Freiberg infraction: head of the second metatarsal
• Friedrich disease: medial clavicle
• Hass disease: humeral head
• Iselin disease: base of 5th metatarsal
• Kienbock disease: lunate
• Kohler disease: patella or navicular (children)
• Kummel disease: vertebral body
• Legg-Calvé-Perthes disease: femoral head
• Liffert-Arkin disease: distal tibia
• Mandl disease: greater trochanter
• Mauclaire disease: metacarpal heads
• Milch disease: ischial apophysis
• Mueller-Weiss disease: navicular (adult)
• Panner disease: capitellum of humerus
• Pierson disease: symphysis pubis
• Preiser disease: scaphoid
• Sever disease: calcaneal epiphysis
• Thiemann disease: base of phalanges
• Van Neck-Odelberg disease: ischiopubic synchondrosis
Location specific sub-articles for avascular necrosis:
•hip avascular necrosis
•scaphoid avascular necrosis
Radiographic changes alter with the stage of AVN – see Ficat staging, Steinberg classification.
In general, there is initial minor osteopenia, followed by variable density. Gradually microfractures of the subchondral bone accumulate in the dead bone, which is unable to repair leading to the collapse of the articular surface and the crescent sign of AVN. Eventually the cortex collapses and fragments, with superimposed secondary degenerative change.
MRI is the most sensitive (~95%) modality and demonstrates changes well before plain films changes are visible.
•diffuse oedema: oedema is not an early sign; instead, studies showed that oedema occurs in advanced stages and is directly correlated with pain
• reactive interface line is a focal serpentine low signal line with fatty centre (most common appearance and first sign on MRI)
• double line sign: serpiginous peripheral/outer dark (sclerosis) and inner bright (granulation tissue) on T2WI is diagnostic
• rim sign: osteochondral fragmentation:
•secondary degenerative change
Bone scintigraphy is also quite sensitive (~85%) and is the second option after MRI. It is a choice when multiple sites of involvement must be assessed in patients with risk factors, such as sickle cell disease. The findings are different accordingly to the time of the scan:
• early disease: often represented by a cold area likely representing the vascular interruption
• late disease: may show a “doughnut sign”: a cold spot with surrounding high uptake ring (surrounding hyperaemia and adjacent synovitis)
Treatment and prognosis
The goal of treatment is to reduce the load on the affected part and to promote revascularisation. Treatment varies with location and includes:
•conservative: anti-inflammatory, analgesia, and reduced/non-weight bearing
•joint replacement for end-stage disease
• MRI and bone scintigraphy have high sensitivity, with MRI studies being the first line for AVN assessment
•differential diagnosis of erosive arthritis
Monoarticular arthropathy can result from a number of causes:
• HADD (hydroxyapatite deposition disease)
What Research Is Being Done to Help People With Osteonecrosis?Some goals of research are to learn more about:How many people have osteonecrosis
Risk factors for osteonecrosisWhy steroids cause osteonecrosisThe role of genesHow to diagnose the disease earlyBetter treatments for osteonecrosisWays to improve hip replacementHow mechanical factors such as the alignment of hips, knees, and ankles affect treatment success.For More Information About Osteonecrosis and Other Related Conditions:
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Information ClearinghouseNational Institutes of Health1 AMS CircleBethesda, MD 20892–3675Phone: 301–495–4484Toll free: 877–22–NIAMS (226–4267) TTY: 301–565–2966Fax: 301–718–6366Email: NIAMSinfo@mail.nih.gov Website: http://www.niams.nih.gov
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I’d like to know what natural remedies or essential oils can you recommend for healing avascular necrosis on shoulder arm pain? Thanks
Well I don’t give medical advice for many reasons the main one is I am not a doctor, I am a patient Leader.
There is no cure for Avascular Necrosis better known as Osteonecrosis although many treatments show promise.
It also depends on how you got Osteonecrosis- was it due to injury or was it from corticosteroids -or a clot disorder-or many of several other factors.
It would also depend on the stage of Osteonecrosis
It’s not a disease that is simple as mixing and rubbing essential oils although that may help with pain or just eating healthy.
Although eating healthy helps with inflammation in persons body.
It’s best to talk to your doctor as they know your history and would know best treatment for you.
Because bone is living tissue that requires blood, an interruption to the blood supply causes bone to die. If not stopped, this process eventually causes the bone to collapse.
Many can try PRP and stem cell injections but it’s not a guarantee.
Some bisphosphonate drugs can help but no cure.
Regenerative medicine treatment. Bone marrow aspirate and concentration is a newer procedure that might be appropriate for early stage avascular necrosis.
Some see relief from hyperbaric oxygen treatment.
So again talk to your doctor.
Other treatments include
Surgical options .
So talk to your doctor and you both can come up with a treatment plan best for you.
Have a great day and good luck.